Complete Bible Study Guide

What Does the Bible Say About Depression?

116 Scripture references with full text and commentary

Understanding Depression in the Bible

Explore what the Bible says about depressed. This collection of 15 key Scripture passages reveals God's wisdom and guidance on this important theme.

116
Total Verses
42
Old Testament
58
New Testament

Top 10 Verses About Depression

  1. 1
    Genesis 21:17
    And God heard the voice of the lad; and the angel of God called to Hagar out of heaven, and said unto her, What aileth thee, Hagar? fear not; for God hath heard the voice of the lad where he is.
    KJV
  2. 2
    Genesis 21:18
    Arise, lift up the lad, and hold him in thine hand; for I will make him a great nation.
    KJV
  3. 3
    Genesis 21:19
    And God opened her eyes, and she saw a well of water; and she went, and filled the bottle with water, and gave the lad drink.
    KJV
  4. 4
    Genesis 21:20
    And God was with the lad; and he grew, and dwelt in the wilderness, and became an archer .
    KJV
  5. 5
    Genesis 37:34
    And Jacob rent his clothes, and put sackcloth upon his loins, and mourned for his son many days.
    KJV
  6. 6
    Genesis 37:35
    And all his sons and all his daughters rose up to comfort him; but he refused to be comforted; and he said, For I will go down into the grave unto my son mourning. Thus his father wept for him.
    KJV
  7. 7
    Genesis 43:14
    And God Almighty give you mercy before the man, that he may send away your other brother, and Benjamin. If I be bereaved of my children, I am bereaved. If: or, And I, as I have been, etc.
    KJV
  8. 8
    Exodus 3:7
    And the LORD said, I have surely seen the affliction of my people which are in Egypt, and have heard their cry by reason of their taskmasters; for I know their sorrows;
    KJV
  9. 9
    Exodus 3:8
    And I am come down to deliver them out of the hand of the Egyptians, and to bring them up out of that land unto a good land and a large, unto a land flowing with milk and honey; unto the place of the Canaanites, and the Hittites, and the Amorites, and the Perizzites, and the Hivites, and the Jebusites.
    KJV
  10. 10
    Exodus 3:9
    Now therefore, behold, the cry of the children of Israel is come unto me: and I have also seen the oppression wherewith the Egyptians oppress them.
    KJV

Subtopics of Depression

being depressed
adolescent depression
anxiety and depression
spiritual depression
grief and sorrow
God takes notice
Of Hagar' s
Of the Israelites
For
No sorrow in heaven
Sorrow and sighing will flee away
Of Hannah
Of David for Absalom
Of Mary and Martha
Of Jeremiah
Of Jesus
From bereavement
Of Jacob for Joseph
For Benjamin
Of the lost

Old Testament: What Does the Bible Say About Depression? (42 Verses)

And God heard the voice of the lad; and the angel of God called to Hagar out of heaven, and said unto her, What aileth thee, Hagar? fear not; for God hath heard the voice of the lad where he is.
Arise, lift up the lad, and hold him in thine hand; for I will make him a great nation.
And God opened her eyes, and she saw a well of water; and she went, and filled the bottle with water, and gave the lad drink.
And God was with the lad; and he grew, and dwelt in the wilderness, and became an archer .
And Jacob rent his clothes, and put sackcloth upon his loins, and mourned for his son many days.
And all his sons and all his daughters rose up to comfort him; but he refused to be comforted; and he said, For I will go down into the grave unto my son mourning. Thus his father wept for him.
And God Almighty give you mercy before the man, that he may send away your other brother, and Benjamin. If I be bereaved of my children, I am bereaved. If: or, And I, as I have been, etc.
And the LORD said, I have surely seen the affliction of my people which are in Egypt, and have heard their cry by reason of their taskmasters; for I know their sorrows;
And I am come down to deliver them out of the hand of the Egyptians, and to bring them up out of that land unto a good land and a large, unto a land flowing with milk and honey; unto the place of the Canaanites, and the Hittites, and the Amorites, and the Perizzites, and the Hivites, and the Jebusites.
Now therefore, behold, the cry of the children of Israel is come unto me: and I have also seen the oppression wherewith the Egyptians oppress them.
Come now therefore, and I will send thee unto Pharaoh, that thou mayest bring forth my people the children of Israel out of Egypt.
Have not I commanded thee? Be strong and of a good courage; be not afraid, neither be thou dismayed: for the LORD thy God is with thee whithersoever thou goest.
And Hannah answered and said, No, my lord, I am a woman of a sorrowful spirit: I have drunk neither wine nor strong drink, but have poured out my soul before the LORD. of a sorrowful: Heb. hard of spirit
And the king was much moved, and went up to the chamber over the gate, and wept: and as he went, thus he said, O my son Absalom, my son, my son Absalom! would God I had died for thee, O Absalom, my son, my son!
And it was told Joab, Behold, the king weepeth and mourneth for Absalom.
And the victory that day was turned into mourning unto all the people: for the people heard say that day how the king was grieved for his son. victory: Heb. salvation, or, deliverance
And the people gat them by stealth that day into the city, as people being ashamed steal away when they flee in battle.
But the king covered his face, and the king cried with a loud voice, O my son Absalom, O Absalom, my son, my son!
And Joab came into the house to the king, and said, Thou hast shamed this day the faces of all thy servants, which this day have saved thy life, and the lives of thy sons and of thy daughters, and the lives of thy wives, and the lives of thy concubines;
In that thou lovest thine enemies, and hatest thy friends. For thou hast declared this day, that thou regardest neither princes nor servants: for this day I perceive, that if Absalom had lived, and all we had died this day, then it had pleased thee well . in: Heb. By loving, etc that thou regardest: Heb. that princes or servants are not to thee
Now therefore arise, go forth, and speak comfortably unto thy servants: for I swear by the LORD, if thou go not forth, there will not tarry one with thee this night: and that will be worse unto thee than all the evil that befell thee from thy youth until now. comfortably: Heb. to the heart of thy servants
Then the king arose, and sat in the gate. And they told unto all the people, saying, Behold, the king doth sit in the gate. And all the people came before the king: for Israel had fled every man to his tent.
The LORD also will be a refuge for the oppressed, a refuge in times of trouble. a refuge: Heb. an high place
The LORD is my rock, and my fortress, and my deliverer; my God, my strength, in whom I will trust; my buckler, and the horn of my salvation, and my high tower. my strength: Heb. my rock
A Psalm of David. The LORD is my shepherd; I shall not want.
Yea, though I walk through the valley of the shadow of death, I will fear no evil: for thou art with me; thy rod and thy staff they comfort me.
For his anger endureth but a moment; in his favour is life: weeping may endure for a night, but joy cometh in the morning. his anger: Heb. there is but a moment in his anger for a night: Heb. in the evening joy: Heb. singing
The righteous cry, and the LORD heareth, and delivereth them out of all their troubles.
The LORD is nigh unto them that are of a broken heart; and saveth such as be of a contrite spirit. unto: Heb. to the broken of heart of a contrite: Heb. contrite of spirit
For this God is our God for ever and ever: he will be our guide even unto death.
Cast thy burden upon the LORD, and he shall sustain thee: he shall never suffer the righteous to be moved. burden: or, gift
He that dwelleth in the secret place of the most High shall abide under the shadow of the Almighty. abide: Heb. lodge
Hear me speedily, O LORD: my spirit faileth: hide not thy face from me, lest I be like unto them that go down into the pit. lest: or, for I am become like, etc
He healeth the broken in heart, and bindeth up their wounds. wounds: Heb. griefs
Trust in the LORD with all thine heart; and lean not unto thine own understanding.
The blessing of the LORD, it maketh rich, and he addeth no sorrow with it.
Heaviness in the heart of man maketh it stoop: but a good word maketh it glad.
And the ransomed of the LORD shall return, and come to Zion with songs and everlasting joy upon their heads: they shall obtain joy and gladness, and sorrow and sighing shall flee away.
Fear thou not; for I am with thee: be not dismayed; for I am thy God: I will strengthen thee; yea, I will help thee; yea, I will uphold thee with the right hand of my righteousness.
He shall see of the travail of his soul, and shall be satisfied: by his knowledge shall my righteous servant justify many; for he shall bear their iniquities.
For I know the thoughts that I think toward you, saith the LORD, thoughts of peace, and not of evil, to give you an expected end. expected: Heb. end and expectation
Is it nothing to you, all ye that pass by? behold, and see if there be any sorrow like unto my sorrow, which is done unto me, wherewith the LORD hath afflicted me in the day of his fierce anger. Is it: or, It is nothing pass by: Heb. pass by the way?

New Testament: What Does the Bible Say About Depression? (58 Verses)

Blessed are they that mourn: for they shall be comforted.
But the children of the kingdom shall be cast out into outer darkness: there shall be weeping and gnashing of teeth.
Come unto me, all ye that labour and are heavy laden, and I will give you rest.
And shall cast them into a furnace of fire: there shall be wailing and gnashing of teeth.
And shall cast them into the furnace of fire: there shall be wailing and gnashing of teeth.
Then said the king to the servants, Bind him hand and foot, and take him away, and cast him into outer darkness; there shall be weeping and gnashing of teeth.
And shall cut him asunder, and appoint him his portion with the hypocrites: there shall be weeping and gnashing of teeth. cut: or, cut him off
And cast ye the unprofitable servant into outer darkness: there shall be weeping and gnashing of teeth.
And he took with him Peter and the two sons of Zebedee, and began to be sorrowful and very heavy.
Then saith he unto them, My soul is exceeding sorrowful, even unto death: tarry ye here, and watch with me.
And he went a little further, and fell on his face, and prayed, saying, O my Father, if it be possible, let this cup pass from me: nevertheless not as I will, but as thou wilt.
And he cometh unto the disciples, and findeth them asleep, and saith unto Peter, What, could ye not watch with me one hour?
Watch and pray, that ye enter not into temptation: the spirit indeed is willing, but the flesh is weak.
He went away again the second time, and prayed, saying, O my Father, if this cup may not pass away from me, except I drink it, thy will be done.
And he came and found them asleep again: for their eyes were heavy.
And he left them, and went away again, and prayed the third time, saying the same words.
And saith unto them, My soul is exceeding sorrowful unto death: tarry ye here, and watch.
And he went forward a little, and fell on the ground, and prayed that, if it were possible, the hour might pass from him.
And he said, Abba, Father, all things are possible unto thee; take away this cup from me: nevertheless not what I will, but what thou wilt.
And he cometh, and findeth them sleeping, and saith unto Peter, Simon, sleepest thou? couldest not thou watch one hour?
Watch ye and pray, lest ye enter into temptation. The spirit truly is ready, but the flesh is weak.
And again he went away, and prayed, and spake the same words.
And when he returned, he found them asleep again, (for their eyes were heavy,) neither wist they what to answer him.
And he cometh the third time, and saith unto them, Sleep on now, and take your rest: it is enough, the hour is come; behold, the Son of man is betrayed into the hands of sinners.
Rise up, let us go; lo, he that betrayeth me is at hand.
There shall be weeping and gnashing of teeth, when ye shall see Abraham, and Isaac, and Jacob, and all the prophets, in the kingdom of God, and you yourselves thrust out.
And in hell he lift up his eyes, being in torments, and seeth Abraham afar off, and Lazarus in his bosom.
Saying, Father, if thou be willing, remove this cup from me: nevertheless not my will, but thine, be done. willing, remove: Gr. willing to remove
And there appeared an angel unto him from heaven, strengthening him.
And being in an agony he prayed more earnestly: and his sweat was as it were great drops of blood falling down to the ground.
Verily, verily, I say unto you, He that heareth my word, and believeth on him that sent me, hath everlasting life, and shall not come into condemnation; but is passed from death unto life.
The thief cometh not, but for to steal, and to kill, and to destroy: I am come that they might have life, and that they might have it more abundantly.
And many of the Jews came to Martha and Mary , to comfort them concerning their brother.
Then Martha, as soon as she heard that Jesus was coming, went and met him: but Mary sat still in the house.
Then said Martha unto Jesus, Lord, if thou hadst been here, my brother had not died.
But I know, that even now, whatsoever thou wilt ask of God, God will give it thee.
Jesus saith unto her, Thy brother shall rise again.
Martha saith unto him, I know that he shall rise again in the resurrection at the last day.
Jesus said unto her, I am the resurrection, and the life: he that believeth in me, though he were dead, yet shall he live:
And whosoever liveth and believeth in me shall never die. Believest thou this?
She saith unto him, Yea, Lord: I believe that thou art the Christ, the Son of God, which should come into the world.
And when she had so said, she went her way, and called Mary her sister secretly, saying, The Master is come, and calleth for thee.
As soon as she heard that, she arose quickly, and came unto him.
Now Jesus was not yet come into the town, but was in that place where Martha met him.
The Jews then which were with her in the house, and comforted her, when they saw Mary, that she rose up hastily and went out, followed her, saying, She goeth unto the grave to weep there.
Then when Mary was come where Jesus was, and saw him, she fell down at his feet, saying unto him, Lord, if thou hadst been here, my brother had not died.
When Jesus therefore saw her weeping, and the Jews also weeping which came with her, he groaned in the spirit, and was troubled , was troubled: Gr. he troubled himself
And said, Where have ye laid him? They said unto him, Lord, come and see.
Jesus wept.
Then said the Jews, Behold how he loved him!
And some of them said, Could not this man, which opened the eyes of the blind, have caused that even this man should not have died?
Jesus therefore again groaning in himself cometh to the grave. It was a cave, and a stone lay upon it.
Jesus said, Take ye away the stone. Martha, the sister of him that was dead, saith unto him, Lord, by this time he stinketh: for he hath been dead four days.
Jesus saith unto her, Said I not unto thee, that, if thou wouldest believe, thou shouldest see the glory of God?
Let not your heart be troubled: ye believe in God, believe also in me.
I will not leave you comfortless: I will come to you. comfortless: or, orphans
If ye abide in me, and my words abide in you, ye shall ask what ye will, and it shall be done unto you.
These things I have spoken unto you, that in me ye might have peace. In the world ye shall have tribulation: but be of good cheer; I have overcome the world.

How to Study What the Bible Says About Depression

  1. 1

    Begin by reading through every verse listed on this page, noting which ones speak most directly to your current season of life. Write them down and revisit them throughout the week.

  2. 2

    Use a concordance or the search tools on this site to find additional passages about depression. Look for patterns across both the Old and New Testaments to gain a complete picture of what God reveals on this subject.

  3. 3

    Study the context of each verse. Read the surrounding chapter to understand who was speaking, who the audience was, and what circumstances prompted the passage. Context prevents misapplication.

  4. 4

    Memorise at least one key verse about depression and meditate on it daily. Scripture memory transforms thinking and equips you to apply God's Word in real-time situations.

Practical Application

Studying what the Bible says about depression is only the beginning. Scripture is meant to be lived out in daily obedience and faith. Here are practical steps to apply these truths:

  • Identify one area of your life where the biblical teaching on depression needs to be applied more consistently. Write a specific, actionable step you can take this week.

  • Share what you have learned about depression with a fellow believer or in a small group setting. Teaching others solidifies your own understanding and encourages mutual growth.

  • Pray through the key verses about depression, asking God to reveal how His Word applies to your relationships, decisions, and daily habits.

How Well Do You Know What the Bible Says About Depression?

You have studied 116 verses about depression. Now test your knowledge with chapter-by-chapter quizzes covering the books where these verses appear.

Frequently Asked Questions

What does the Bible say about depression?
Explore what the Bible says about depressed. This collection of 15 key Scripture passages reveals God's wisdom and guidance on this important theme. The Bible contains 116 key verses about depression spanning both Old and New Testaments.
How many Bible verses about depression are there?
There are 116 key Bible verses about depression compiled in this study guide, drawn from books across both the Old and New Testaments.
What is the best verse about depression?
One of the most well-known and frequently cited verses about depression is Genesis 21:17 — "And God heard the voice of the lad; and the angel of God called to Hagar out of heaven, and said unto her, What aileth thee, Hagar? fear not; for God ..."
Where in the Bible does it talk about depression?
Depression is discussed throughout the Bible in both the Old and New Testaments. You can find 116 references to this topic across multiple books including the Psalms, Proverbs, the Gospels, and the Epistles.

Continue Studying Depression

Topics Included

This page consolidates Bible verses from 7 related topics:

depresseddepressiondespairsadnesssorrow